- Immunology and Serology in Laboratory Medicine, 7th Edition
(Turgeon, 2022), Chapter 1-27 | Fully Updated!!!
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Immunology and Serology in Laboratory Medicine, 7th Edition by Mary Louise Turgeon
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Chapter 1-27 x
Chapter 01: Highlights of the Innate and Adaptive Immune Systems
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MULTIPLE CHOICE x
1. The ―father‖ of immunology is generally considered to be
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a. Koch.
b. Pasteur.
c. Gram.
d. Salk.
ANS: B x
Louis Pasteur is generally considered to be the ―father of immunology.‖
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DIF: Cognitive Level: I x x
2. An early form of immunization was practiced by the
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a. Romans.
b. Greeks.
c. Chinese.
d. Native Americans. x
ANS: C x
Beginning about 1000 AD, the Chinese practiced a form of immunization by inhaling dried
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powders derived from the crusts of smallpox lesions.
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DIF: Cognitive Level: I x x
3. A specific function of the immune system is to
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a. recognize self from nonself. x x x
b. defend the body against nonself. x x x x
c. amplify specific functions. x x
d. Both A and B. x x x
ANS: D x
The function of the immune system is to recognize self from nonself and defend the body
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against nonself. Such a system is necessary for survival. The immune system also has
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nonspecific effector mechanisms that usually amplify the specific functions. Nonspecific
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components of the immune system include mononuclear phagocytes, polymorphonuclear
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leukocytes, and soluble factors (e.g., complement).
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DIF: Cognitive Level: I x x
4. An undesirable consequence of immunity is
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a. natural resistance. x
b. acquired resistance to infectious diseases. x x x x
, c. an autoimmune disorder.
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d. recovery from infectious disease. x x x
ANS: C x
The desirable consequences of immunity include natural resistance, recovery, and acquired
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resistance to infectious diseases. A deficiency or dysfunction of the immune system can cause
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many disorders. Undesirable consequences of immunity include allergy, rejection of a
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transplanted organ, or an autoimmune disorder.
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DIF: Cognitive Level: I x x
5. The immune system has various distinctive characteristics except;
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a. specificity.
b. memory.
c. mobility.
d. noncooperation among different cells. x x x
ANS: D x
The immune system is composed of a large, complex set of widely distributed elements, with
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the distinctive characteristics of specificity, memory, mobility, replicability, and cooperation
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among different cells or cellular products. Specificity and memory are characteristics of
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lymphocytes in the immune system. Nonspecific elements of the immune system demonstrate
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mobility. In addition, specific and nonspecific cellular components of the immune system can
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replicate. Cooperation is required for optimal functioning, and interaction involves specific
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cellular elements, cell products, and nonlymphoid elements.
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DIF: Cognitive Level: I x x
6. Hematopoiesis occurs in the yolk sac during the x x x x x x x
a. immediate hours after conception x x x
b. second month of gestation. x x x
c. second trimester of gestation.x x x
d. periods of severe anemia in children.
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ANS: A x
The sites of blood cell development, or hematopoiesis, follow a definite sequence in the
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embryo and fetus. Hematopoiesis occurs in the yolk sac during the second month of gestation.
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DIF: Cognitive Level: II x x
7. The sequence of blood cell development in the embryo and fetus is
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a. yolk sac, liver-spleen, bone marrow.
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b. yolk sac, bone marrow, liver/spleen.
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c. liver-spleen, yolk sac, bone marrow. x x x x
d. bone marrow, liver-spleen, yolk sac.
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ANS: A x
, The first blood cells are primitive red blood cells (erythroblasts; RBCs) formed in the islets of
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the yolk sac during the first 2 to 8 weeks of life. Gradually, the liver and spleen replace the
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yolk sac as the sites of blood cell development. By the second month of gestation, the liver
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becomes the major site of hematopoiesis, and granular types of leukocytes have made their
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initial appearance. The liver and spleen predominate from about 2 to 5 months of fetal life. In
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the fourth month of gestation, bone marrow begins to produce blood cells. After the fifth fetal
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month, bone marrow begins to assume its ultimate role as the primary site of hematopoiesis.
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DIF: Cognitive Level: II x x
8. The primary function of mature neutrophils is
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a. to reduce inflammation.
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b. to lyse parasites in the circulatory system.
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c. antigen recognition. x
d. phagocytosis.
ANS: D x
Various phagocytic cells continually circulate throughout the blood, lymph, gastrointestinal
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system, and respiratory tract. When trauma occurs, the neutrophils arrive at the site of injury
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and can be found in the initial exudate in less than 1 hour. Monocytes are slower in moving to
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the inflammatory site. Macrophages resident in the tissues of the body are already in place to
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deal with an intruding agent. Additional macrophages from the bone marrow and other tissues
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can be released in severe infections.
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DIF: Cognitive Level: II x x
9. Primary granules, or azurophilic granules, in neutrophils contain
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a. lysozyme.
b. myeloperoxidase.
c. lactoferrin.
d. Both A and B. x x x
ANS: D x
Granules in the phagocyte cytosol contain degradatory enzymes of three types
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1. Primary, or azurophilic, granules containing enzymes (e.g., lysozyme, x x x x x x x
myeloperoxidase) x
2. Secondary, or specific, granules containing substances such as lactoferrin. x x x x x x x x
3. Tertiary granules containing substances such as caspases x x x x x x
DIF: Cognitive Level: I x x
10. The origin of a condition when eosinophils are increased in the circulating blood is associated
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xwith:
a. fungus
b. parasitic amoeba x
c. allergic reactions x
d. bacteria
ANS: C x