NR-704 NR704 Exam Prep 2025-2026:
Complete Question Bank with Rationales for
Advanced Nurse Practitioners
1. Which of the following is the first-line treatment for
hypertension in a patient with chronic kidney disease?
A. Hydrochlorothiazide
B. ACE inhibitor
C. Atenolol
D. Verapamil
Rationale: ACE inhibitors are first-line in CKD because they
reduce proteinuria and slow progression of kidney disease.
2. A patient is prescribed warfarin. Which lab test is most
appropriate to monitor therapy?
A. PT
B. CBC
C. INR
D. aPTT
Rationale: INR standardizes PT and is the preferred test for
monitoring warfarin anticoagulation.
3. Which medication is classified as a loop diuretic?
,A. Hydrochlorothiazide
B. Spironolactone
C. Furosemide
D. Mannitol
Rationale: Furosemide inhibits the Na-K-2Cl transporter in the
ascending loop of Henle.
4. Which antibiotic is contraindicated in pregnancy due to
teratogenicity?
A. Amoxicillin
B. Cephalexin
C. Tetracycline
D. Azithromycin
Rationale: Tetracyclines can affect fetal bone and teeth
development.
5. Which of the following drugs is a beta-1 selective blocker?
A. Propranolol
B. Metoprolol
C. Carvedilol
D. Labetalol
Rationale: Metoprolol selectively blocks beta-1 receptors,
reducing cardiac effects while sparing beta-2 lungs.
,6. A patient taking statins should be monitored for:
A. Kidney function
B. Liver function tests
C. Blood glucose
D. CBC
Rationale: Statins can cause hepatotoxicity; LFTs should be
monitored.
7. Which is the antidote for acetaminophen overdose?
A. Flumazenil
B. N-acetylcysteine
C. Atropine
D. Naloxone
Rationale: N-acetylcysteine replenishes glutathione to prevent
liver injury.
8. Which class of drugs is indicated for heart failure with
reduced ejection fraction (HFrEF) to improve mortality?
A. Calcium channel blockers
B. NSAIDs
C. ACE inhibitors
D. Loop diuretics
Rationale: ACE inhibitors reduce morbidity and mortality in
HFrEF patients.
, 9. Which of the following reduces the risk of
thromboembolism in atrial fibrillation?
A. Aspirin
B. Direct oral anticoagulants (DOACs)
C. Clopidogrel alone
D. Warfarin only in mechanical valves
Rationale: DOACs are preferred over warfarin for non-valvular
AF due to safety and convenience.
10. Which medication is used to reverse the effects of
heparin?
A. Vitamin K
B. Protamine sulfate
C. Protamine sulfate
D. N-acetylcysteine
Rationale: Protamine sulfate binds heparin and neutralizes its
anticoagulant effect.
11. Which class of drugs is commonly used to treat
hyperthyroidism?
A. Levothyroxine
B. Methimazole
C. Liothyronine
Complete Question Bank with Rationales for
Advanced Nurse Practitioners
1. Which of the following is the first-line treatment for
hypertension in a patient with chronic kidney disease?
A. Hydrochlorothiazide
B. ACE inhibitor
C. Atenolol
D. Verapamil
Rationale: ACE inhibitors are first-line in CKD because they
reduce proteinuria and slow progression of kidney disease.
2. A patient is prescribed warfarin. Which lab test is most
appropriate to monitor therapy?
A. PT
B. CBC
C. INR
D. aPTT
Rationale: INR standardizes PT and is the preferred test for
monitoring warfarin anticoagulation.
3. Which medication is classified as a loop diuretic?
,A. Hydrochlorothiazide
B. Spironolactone
C. Furosemide
D. Mannitol
Rationale: Furosemide inhibits the Na-K-2Cl transporter in the
ascending loop of Henle.
4. Which antibiotic is contraindicated in pregnancy due to
teratogenicity?
A. Amoxicillin
B. Cephalexin
C. Tetracycline
D. Azithromycin
Rationale: Tetracyclines can affect fetal bone and teeth
development.
5. Which of the following drugs is a beta-1 selective blocker?
A. Propranolol
B. Metoprolol
C. Carvedilol
D. Labetalol
Rationale: Metoprolol selectively blocks beta-1 receptors,
reducing cardiac effects while sparing beta-2 lungs.
,6. A patient taking statins should be monitored for:
A. Kidney function
B. Liver function tests
C. Blood glucose
D. CBC
Rationale: Statins can cause hepatotoxicity; LFTs should be
monitored.
7. Which is the antidote for acetaminophen overdose?
A. Flumazenil
B. N-acetylcysteine
C. Atropine
D. Naloxone
Rationale: N-acetylcysteine replenishes glutathione to prevent
liver injury.
8. Which class of drugs is indicated for heart failure with
reduced ejection fraction (HFrEF) to improve mortality?
A. Calcium channel blockers
B. NSAIDs
C. ACE inhibitors
D. Loop diuretics
Rationale: ACE inhibitors reduce morbidity and mortality in
HFrEF patients.
, 9. Which of the following reduces the risk of
thromboembolism in atrial fibrillation?
A. Aspirin
B. Direct oral anticoagulants (DOACs)
C. Clopidogrel alone
D. Warfarin only in mechanical valves
Rationale: DOACs are preferred over warfarin for non-valvular
AF due to safety and convenience.
10. Which medication is used to reverse the effects of
heparin?
A. Vitamin K
B. Protamine sulfate
C. Protamine sulfate
D. N-acetylcysteine
Rationale: Protamine sulfate binds heparin and neutralizes its
anticoagulant effect.
11. Which class of drugs is commonly used to treat
hyperthyroidism?
A. Levothyroxine
B. Methimazole
C. Liothyronine
